Molecular Imaging Platform Leverages Hyb & Seq Chemistry to Spatially Profile Expression of 1,000+ Genes at Single Cell and Sub-Cell Resolution Across Tissue Samples
Available in Technology Access Program in H1-2021 with Commercial Instrument Launch Expected in H2-2022
Details to be Shared During Investor and Analyst Day on
The spatial molecular imager combines the power of high-plex profiling with high-resolution imaging to enable the analysis of hundreds to thousands of RNAs or proteins directly from single cells within morphologically intact tissue samples. The platform utilizes the company’s advanced Hyb & Seq chemistry, which over the last 18 months has been optimized for in situ spatial analysis. The platform is capable of profiling RNA and protein within a single cell down to sub-cellular resolution in multiple tissue types. To date, prototype systems have imaged RNA from as many as 1,000+ genes simultaneously across thousands of individual cells in Formalin-Fixed Paraffin Embedded (FFPE) tissue.
Tissue biology takes place on several spatial scales including multi-cellular, single cell and the sub-cellular levels. The GeoMx® Digital Spatial Profiler (DSP) enables multi-cellular analysis at the whole transcriptome level to elucidate the behavior of populations of cells, such as those within a tumor or the tumor microenvironment.
“Spatial imagers measuring RNA and protein in situ at single-cell and sub-cell resolution are expected to emerge as an important product category over the next several years,” said
“Researchers and clinicians have gained tremendous insights from the revolution in single cell biology in recent years, but the cellular context was always lost,” said
“Spatial molecular imaging opens up new possibilities to understand the diversity of T-cells infiltrating a tumor at the single cell level without dissociating tissue. Our work under the Technology Access Program has produced results on the location of different T-cell subsets and their interaction with tumors and could reveal which T-cell subsets are most important for controlling tumors,” said
The company plans to provide researchers access to the prototype versions of spatial molecular imaging platform through a Technology Access Program (TAP) beginning in 2021. Under the program, a TAP customer can submit tissue samples to
The Hyb & Seq chemistry was originally developed as part of a hybridization-based sequencing program. The company formed a strategic collaboration with Lam Research, under which Lam Research provided
The company is hosting an Investor and Analyst Day webcast at
Researchers interested in participating in NanoString’s Technology Access Program should contact us at TAP@nanostring.com.
To learn more about NanoString’s GeoMx Digital Spatial Profiler, please visit https://www.nanostring.com/products/geomx-digital-spatial-profiler/geomx-dsp.
For more information, please visit www.nanostring.com.
Vice President, Investor Relations & Corporate Communications