Deep Molecular Profiling of Immune Cells Critical for Survival and Response to Therapy in Patients with Metastatic Melanoma
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GeoMx DSP Helps to Uncover Role of B cells in Response to Immunotherapy (Photo: Business Wire)
The first publication, “B-cells and tertiary lymphoid structures (TLS) contribute to immune checkpoint blockade response,” from the team of Dr.
B-cells are adaptive immune cells that produce antibodies and mediate T-cell activation. Recently, the presence of B-cells in the tumor microenvironment has been recognized as a prognostic marker for immunotherapy response. However, the mechanisms by which they contribute to anti-tumor immunity are difficult to determine as their phenotype and behavior differ significantly based on location within the tumor. Notably, B-cells can concentrate in specialized lymphoid organs known as tertiary lymphoid structures (TLS). The B-cells, T-cells, and antigen presenting cells comprising the TLS have distinct phenotypes and functions when compared to non-TLS immune cells. Dissection of the roles and mechanisms that these cells play in the tumor immune environment requires the use of spatially driven multiplex technology such as GeoMx DSP.
“The multiplex GeoMx DSP platform enabled us to specifically define the immune phenotype of tumor-infiltrating and TLS-localized B-cells and T-cells in the tumor sample,” said
The second study, “Tertiary lymphoid structures improve melanoma survival and immunotherapy response,” led by Dr. Göran Jönsson at the
“We used the GeoMx platform to better understand the mechanism by which the presence of TLS lead to improved outcomes,” said Dr. Jönsson. “We found that infiltrating T-cells in tumors without TLS show a dysfunctional molecular phenotype, suggesting that distinct patterns of intratumoral adaptive immune activation may be partly driven by B-cells.”
“These concurrent studies demonstrate the ability of GeoMx DSP to deliver unique and impactful biological insights that advance the field on immuno-oncology,” said
The GeoMx Digital Spatial Profiler enables researchers to rapidly and quantitatively characterize tissue morphology with a high-throughput, high-plex RNA and protein profiling system that preserves samples for future analyses.
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