"We're excited by the volume and impact of the important translational research that our customers and collaborators are presenting at the meeting of the
The ASH Annual Meeting, being held
- Analytical validation of the investigational nCounter®-based Lymphoma Subtyping Test for cell-of-origin (COO) identification in Formalin-Fixed Paraffin-Embedded (FFPE) Diffuse Large B-Cell Lymphoma (DLBCL) Specimens. The data show that this assay provides a highly precise, sensitive and rapid method for measuring COO on FFPE DLBCL tumor specimens, including both excisional and core needle biopsies. This assay is currently being used to select patients for a phase 3 clinical
trial to evaluate lenalidomide plus R-CHOP versus placebo plus R-CHOP in patients who have newly diagnosed, previously untreated
ABC-type DLBCL (Abstract #2933).
- Data on outcomes by COO as determined via the investigational NanoString Lymphoma Subtyping Test on patients enrolled in a phase 2 study of lenalidomide combined with R-CHOP (R2CHOP) and an independent comparison cohort of patients treated with R-CHOP alone. The results show that R2CHOP demonstrates promising efficacy in
ABC-type DLBCL as defined by the NanoStringassay, where the addition of lenalidomide to R-CHOP appears to mitigate the negative prognostic impact of the ABCsubtype in newly diagnosed DLBCL (Abstract #3035).
- Results from an open-Label, randomized phase 3 study (GOYA) comparing the
efficacy and safety of obinutuzumab plus CHOP (G-CHOP) with R-CHOP in patients with previously untreated DLBCL. A pre-specified secondary analysis of cell-of-origin by the investigational NanoString Lymphoma Subtyping Test showed a trend toward benefit from Gazyva in GCB-type DLBCL. (Abstract #470).
- Data on the first analysis of an international double-blind randomized phase 3 Study (
REMARC) of lenalidomide maintenance in elderly patients with DLBCL treated with R-CHOP in first line, which include cell-of-origin analysis assessed by the NanoString Lymphoma Subtyping Test (Abstract #471).
The 2016 ASH abstracts describe research and clinical applications that underscore the diverse capabilities of the nCounter platform, which
|2933||Analytical Validation of the nCounter®-based Lymphoma Subtyping Test (LST) for Cell-of-Origin (COO) Identification in Formalin-Fixed Paraffin-Embedded (FFPE) Diffuse Large B-Cell Lymphoma (DLBCL) Specimens||https://ash.confex.com/ash/2016/webprogram/Paper93666.html|
|3035||Lenalidomide Combined with R-CHOP (R2CHOP) Overcomes Negative Prognostic Impact of ABC Molecular Subtype in Newly Diagnosed Diffuse Large B-Cell Lymphoma||https://ash.confex.com/ash/2016/webprogram/Paper95550.html|
|470||Obinutuzumab or Rituximab Plus CHOP in Patients with Previously Untreated Diffuse Large B-Cell Lymphoma: Final Results from an Open-Label, Randomized Phase 3 Study (GOYA)||https://ash.confex.com/ash/2016/webprogram/Paper96159.html|
|471||First Analysis of an International Double-Blind Randomized Phase III Study of Lenalidomide Maintenance in Elderly Patients with DLBCL Treated with R-CHOP in First Line, the Remarc Study from Lysa||https://ash.confex.com/ash/2016/webprogram/Paper91527.html|
|474||Lenalidomide Maintenance Significantly Improves Survival Figures in Patients with Relapsed Diffuse Large B-Cell Lymphoma (rDLBCL) Who Are Not Eligible for Autologous Stem Cell Transplantation (ASCT): Final Results of a Multicentre Phase II Trial||https://ash.confex.com/ash/2016/webprogram/Paper96221.html|
|152||Integrating Genomic Alterations in Diffuse Large B-Cell Lymphoma Identifies New Relevant Pathways and Potential Therapeutic Targets||https://ash.confex.com/ash/2016/webprogram/Paper94639.html|
|2935||Whole-Exome Analysis Reveals Novel Somatic Genomic Alterations Associated with Cell of Origin in Diffuse Large B-Cell Lymphoma||https://ash.confex.com/ash/2016/webprogram/Paper96566.html|
|1107||Pembrolizumab in Relapsed/Refractory Classical Hodgkin Lymphoma: Primary End Point Analysis of the Phase 2 Keynote-087 Study||https://ash.confex.com/ash/2016/webprogram/Paper97284.html|
|619||Phase 1b Study of Pembrolizumab in Patients with Relapsed/Refractory Primary Mediastinal Large B-Cell Lymphoma: Results from the Ongoing Keynote-013 Trial||https://ash.confex.com/ash/2016/webprogram/Paper93580.html|
|918||A Novel Anti-Lymphoma Immune Evasion Mediated By the Interaction Between PD-1 Enriched NK-Cells and CD163+PD-L1+PD-L2+ Tumor Associated Macrophages, That Is More Prominent in Hodgkin Lymphoma Than Diffuse Large B-Cell Lymphoma||https://ash.confex.com/ash/2016/webprogram/Paper92109.html|
|4576||Differential Expression of Immunity Related Genes and Early Prediction of Severe Graft Versus Host Disease after Allogeneic Hematopoietic Cell Transplantation||https://ash.confex.com/ash/2016/webprogram/Paper97711.html|
|1954||Transcriptional Characterization of Myelofibrotic Bone Marrow Microenvironment Reveals Distinct Tumor Microenvironment in JAK2+ and Calr+ PMF Marrows||https://ash.confex.com/ash/2016/webprogram/Paper97124.html|
|1664||Microvesicles microRNAs Reflect and Affect Progression of Acute Myeloid Leukemia and Could Serve As a Biomarker of Disease Dynamics||https://ash.confex.com/ash/2016/webprogram/Paper90648.html|
|3285||Integrative Network Analysis of Newly Diagnosed Multiple Myeloma Identifies a Novel RNA-Seq Based High Risk gene Signature||https://ash.confex.com/ash/2016/webprogram/Paper97575.html|
For more information, please visit www.nanostring.com.
Doug FarrellVice President, Investor Relations & Corporate Communications firstname.lastname@example.org Phone: 206-602-1768
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