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NanoString Highlights a Record Number of nCounter-Based Research Abstracts in Precision Oncology and Predictive Biomarkers at the 2017 American Association of Cancer Research (AACR) Annual Meeting

SEATTLE, March 27, 2017 (GLOBE NEWSWIRE) -- NanoString Technologies, Inc. (NASDAQ:NSTG), a provider of life science tools for translational research and molecular diagnostic products, today announced the upcoming presentation of recent research in precision oncology and predictive biomarkers using the nCounter® Analysis System. More than 45 NanoString-related abstracts will be presented at the Annual Meeting of the American Association of Cancer Research (AACR), which is being held April 1-5, 2017, in Washington, DC.

"We are proud to see our products and technologies being used so broadly to advance the understanding of cancer. We salute these researchers and the groundbreaking contributions to cancer research that are being presented at the 2017 Annual Meeting of the AACR," said Brad Gray, president and chief executive officer of NanoString Technologies. "Our nCounter technology has become an essential tool for biomarker research, and we continue to expand the capabilities and content to drive adoption in other areas of research such as autoimmune syndromes, infectious disease and neurology."

The 2017 AACR abstracts describe research applications that underscore the diverse capabilities and robust performance of the nCounter platform. These studies cover a wide range of cancers, tissue types (FFPE, peripheral blood and urine), and treatment modalities. There are at least 33 abstracts authored by academic researchers and 13 by biopharma researchers. These abstracts span translational research from biomarker validation and disease characterization, to drug resistance and autoimmune toxicities of checkpoint inhibitors.

NanoString will be exhibiting at AACR (booth# 3115) and hosting a workshop entitled "Powering Precision Oncology Research with 3D Biology Technology: High Plex Multi-Analyte Profiling on FFPE with Spatial Resolution" at 10:00am ET on Monday April 3

Abstract #TitleHyperlink
471/12HER2 regulates PARP-1 expression by suppressing the let-7a microRNA in HER2+ breast cancer!/4292/presentation/2057
414/14Identifying selective vulnerabilities in colorectal cancer molecular subtypes using in vivo functional genomic screens!/4292/presentation/6665
811/17Histological heterogeneity contributes to sunitinib resistance in clear cell renal cell carcinoma!/4292/presentation/1784
588/22Advanced molecular characterization of severe autoimmune toxicities associated with checkpoint inhibitor therapies!/4292/presentation/6096
491/5Elucidating de novo PATRR-mediated t(3;8) balanced translocation and clear cell renal cell carcinoma!/4292/presentation/1159
829/7MicroRNA regulation of radiation sensitivity in colorectal cancer!/4292/presentation/2397
1682/1Correlation of immune co-stimulatory molecule OX40 and outcome in trastuzumab treated HER2-positive breast cancer patients in the NCCTG-N9831.!/4292/presentation/5987
1750/10Analysis of non-metastatic HCC patient tumors revealed the significance of cell cycle regulation and tumor immunity in association with overall survival and identified clinically relevant druggable targets!/4292/presentation/2931
1469/11Integrated analysis of microRNA, mRNA, and protein expression utilizing MultiOmyx and NanoString from formalin-fixed paraffin-embedded, lung, head and neck, breast, and melanoma tumors!/4292/presentation/2080
1785/15Technical validation of novel 325 RNA predictive biomarkers using gene expression data generated by Nanostring n-counter and Affymetrix microarray!/4292/presentation/1589
1904/5Novel 5-fluorouracil-thymoquinone hybrid kills colon cancer stem cells!/4292/presentation/5919
2088/15The activity of the FGFR selective inhibitor Debio 1347 is correlated with high mRNA expression!/4292/presentation/3926
2841/14Investigating drivers of disease progression in invasive lobular carcinoma!/4292/presentation/3513
2441/28NanoString 3D Biology technology: simultaneous digital counting of DNA, RNA and protein!/4292/presentation/6870
2251/5Tumor tissue gene expression in association with survival of triple-negative breast cancer!/4292/presentation/2562
2422/9Simultaneous detection of activating somatic DNA mutations and expressed fusion transcripts from lung tumor FFPE samples!/4292/presentation/6827
3814/10A pan cancer analysis of the tumor inflammation signature!/4292/presentation/1652
3612/11Combination FGFR4 and ER-targeted therapy for invasive lobular carcinoma!/4292/presentation/2276
3431/11The oncogenic role of miR-150-5p in triple-negative breast cancer!/4292/presentation/2127
3706/19Validation of human and mouse myeloid panels on the NanoString nCounter Platform!/4292/presentation/3240
3738/23Use of tumor mRNA expression for patient selection in a phase I study of the pan-fibroblast growth factor receptor inhibitor BAY 1163877!/4292/presentation/3003
3955/22Spatially resolved, multiplexed digital characterization of protein and mRNA distribution and abundance in formalin-fixed, paraffin-embedded (FFPE) tissue sections based on NanoString's Digital Spatial Profiling (DSP) technology: applications to immuno-oncology (IO) and tumor heterogeneity!/4292/presentation/3416
3652/25Combinational activity of LAG3 and PD-1 targeted therapies is significantly enhanced by the addition of phosphatidylserine targeting antibodies and establishes an anti-tumor memory response in murine triple negative breast cancer!/4292/presentation/6260
3983/26A cross comparison of technologies for the detection of immune system related gene expression signatures in clinical FFPE samples of metastatic prostate cancer patients!/4292/presentation/9068
3684/27Inhibition of STAT3 by antisense oligonucleotide treatment decreases the immune suppressive tumor microenvironment in syngeneic and GEM tumor models!/4292/presentation/6345
3423/3Elucidation of the role of miR-575 on tumorigenesis in glioblastoma!/4292/presentation/2119
3810/6Validation of novel high-plex protein spatial profiling quantitation based on NanoString's Digital Spatial Profiling (DSP) technology with quantitative fluorescence (QIF)!/4292/presentation/1648
3377/8Simultaneous analysis of the mutational landscape and RNA and protein expression profile of HER2-positive breast cancer using 3D Biology!/4292/presentation/6631
NG04Mechanisms of resistance to anti-PD-1 immunotherapy through interferon pathway mutations!/4292/presentation/11061
4649/10Development of an ethnicity informed gene expression panel with potential to improve prostate cancer diagnosis!/4292/presentation/1628
4334/13Interleukin-6 is a key player in stroma-induced resistance to chemotherapy for gastric carcinomas!/4292/presentation/5224
4387/19The clonal composition of colorectal cancer cell lines is defined by the maintenance of specific genomic imbalances, not by ongoing chromosomal instability!/4292/presentation/6569
4197/20Interaction of B lymphoma cells with the microenvironment affects ibrutinib sensitivity!/4292/presentation/3904
4442/20micoRNA in FA defective tumor!/4292/presentation/2156
4262/28Inflammatory gene expression differences among prostate cancer patients exposed to the World Trade Center aftermath!/4292/presentation/4794
4971IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors!/4292/presentation/3226
5000A stromal liver gene signature predictive of HCC risk across all liver disease etiologies!/4292/presentation/7455
5095/11Development of a pharmacodynamic biomarker assay for AZD4785, an antisense oligonucleotide targeting KRAS!/4292/presentation/2614
5448/13An exosomal biomarker for prostate cancer!/4292/presentation/2172
5645/17Associations between biomarkers and outcome in a patient cohort with invasive lobular carcinoma!/4292/presentation/993
5563/213D Biology view of cancer: Simultaneous detection of somatic DNA mutations and expression profiling of genes and signaling proteins from melanoma tumor FFPE samples!/4292/presentation/1756
5726/20A novel tumor-promoting role for miR-4516 in glioblastoma!/4292/presentation/1479
5757/21Study of human mammary tumor virus (HMTV) in human breast cancer by NanoString nCounter and FISH analysis!/4292/presentation/2332
5652/6Translational evidence of reactivated innate and adaptive immunity with intratumoral IMO-2125 in combination with systemic checkpoint inhibitors from a Phase I/II study in patients with anti-PD-1 refractory metastatic melanoma!/4292/presentation/6014
5350/6A comprehensive and integrated approach to genomic and proteomic analysis of FFPE NSCLC tumor specimens!/4292/presentation/6724
5092/8ZVex lentiviral vector strongly activates pro-inflammatory, antigen processing, and antiviral defense response pathways in monocyte-derived dendritic cells!/4292/presentation/2611

About NanoString Technologies, Inc.
NanoString Technologies provides life science tools for translational research and molecular diagnostic products. The company's nCounter Analysis System has been employed in life sciences research since it was first introduced in 2008 and has been cited in more than 1500 peer-reviewed publications. The nCounter Analysis System offers a cost-effective way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision, facilitating a wide variety of basic research and translational medicine applications, including biomarker discovery and validation. The company's technology is also being used in diagnostics. The Prosigna® Breast Cancer Prognostic Gene Signature Assay together with the nCounter Dx Analysis System is FDA 510(k) cleared for use as a prognostic indicator for distant recurrence of breast cancer. In addition, the company is collaborating with multiple biopharmaceutical companies in the development of companion diagnostic tests for various cancer therapies, helping to realize the promise of precision oncology.

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The NanoString Technologies logo, NanoString, NanoString Technologies, nCounter, 3D Biology, and Prosigna are registered trademarks or trademarks of NanoString Technologies, Inc. in various jurisdictions.



Doug Farrell

Vice President, Investor Relations & Corporate Communications

Phone: 206-602-1768 

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Source: NanoString Technologies

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