“The introduction of the
“Quantitative measures to profile CART-T cell therapeutics are important to understand what we are delivering to patients. Companies like
“As CAR-T products join the therapeutic armamentarium in oncology, product characterization and optimization will greatly benefit from more sophisticated and quantitative analysis, leading to acceleration of the development process in this space,” said Adrian Bot, M.D., Ph.D., vice president Translational Medicine at Kite Pharma, a
Adoptive Cell Therapy (ACT) is a rapidly emerging approach to immunotherapy, despite its long history in translational labs and the clinic. There are several different types of ACT, but the one that has demonstrated the most clinical promise to date is chimeric antigen receptor, or CAR-T cell therapy. CAR-T therapy represents a new and challenging class of “living drugs”, as a patient’s own T-cells are used to develop the drug product and the therapeutic can persist for years post-treatment in patients. With the approval of two CAR-T products over the past year, the field has experienced a significant increase in momentum with over 600 active studies worldwide and 100+ pharmaceutical, biotechnology and specialized cancer centers with a focus on CAR-T therapy. Along with that momentum, there is recognition that significant challenges remain. In particular, standardizing a manufacturing process dependent on highly variable inputs and complex biology has proven to be one of the greatest unmet needs. The field is also highly focused on understanding the factors that influence efficacy, safety and utility in a broader variety of tumor types.
NanoString Technologies provides life science tools for translational research and molecular diagnostic products. The company's nCounter® Analysis System has been employed in life sciences research since it was first introduced in 2008 and has been cited in more than 2,000 peer-reviewed publications. The nCounter Analysis System offers a cost-effective way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision, facilitating a wide variety of basic research and translational medicine applications, including biomarker discovery and validation. The company's technology is also being used in diagnostics. The Prosigna® Breast Cancer Prognostic Gene Signature Assay together with the nCounter Dx Analysis System is FDA 510(k) cleared for use as a prognostic indicator for distant recurrence of breast cancer. In addition, the company collaborates with biopharmaceutical companies in the development of companion diagnostic tests for various cancer therapies, helping to realize the promise of precision oncology.
For more information, please visit www.nanostring.com.
Vice President, Investor Relations & Corporate Communications
Source: NanoString Technologies, Inc.