Translational Research Initiative Will Use PanCancer IO 360 Panel to Identify Predictive Signatures for MGD013
MGD013 is an IgG4κ bispecific DART® molecule designed to simultaneously block the PD-1 and LAG-3 pathways. In preclinical studies, MGD013 provides enhanced T-cell activation compared to single or combination monoclonal antibody blockade. Disrupting these non-redundant inhibitory pathways may further restore exhausted T-cell function and enhance anti-tumor efficacy. MGD013 is currently in the dose escalation portion of a Phase 1/2 study in which tolerability and preliminary safety in advanced solid tumors and hematologic malignancies are being evaluated.
“This collaboration presents a unique opportunity to accelerate our MGD013 clinical development program by applying NanoString’s translational research tools,” said
“We are excited to be collaborating with
The PanCancer IO 360 panel is designed for clinical translational research applications including identification of predictive biomarkers. The panel is designed around the Tumor Inflammation Signature (TIS), an 18 gene signature which measures the presence or absence of a peripherally suppressed adaptive immune response, biology which is relevant to the mechanism of action of MGD013.
About the PanCancer IO 360
NanoString’s PanCancer IO 360
NanoString Technologies provides life science tools for translational research and molecular diagnostic products. The company's nCounter® Analysis System has been employed in life sciences research since it was first introduced in 2008 and has been cited in more than 2,000 peer-reviewed publications. The nCounter Analysis System offers a cost-effective way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision, facilitating a wide variety of basic research and translational medicine applications, including biomarker discovery and validation. The company's technology is also being used in diagnostics. The Prosigna® Breast Cancer Prognostic Gene Signature Assay together with the nCounter Dx Analysis System is FDA 510(k) cleared for use as a prognostic indicator for distant recurrence of breast cancer. In addition, the company collaborates with biopharmaceutical companies in the development of companion diagnostic tests for various cancer therapies, helping to realize the promise of precision oncology.
For more information, please visit www.nanostring.com.
Vice President, Investor Relations & Corporate Communications
Source: NanoString Technologies, Inc.